教育经历
2011.09-2015.06 河北科技大学-制药工程-学士
2015.09-2018.06 河北科技大学-制药工程-硕士
2018.09-2022.09 华东理工大学-药学-博士（导师：钱旭红院士 李洪林教授）
工作经历
2022.10-2024.10 华东师范大学-博士后（合作导师：李洪林教授）
2024.10至今 华东师范大学药学院 专任副研究员
研究方向
药物化学：自身免疫性疾病及抗肿瘤药物研究
药物智造：基于连续流的药物智能合成
联系方式
代表性论文
1.Huan He#, Xingsen Zhang#, Jie Wang#, Qi Liu#, LeiHao Zhang, Lu Chen, Yuan Yuan, Zhenjiang Zhao*, Honglin Li*, and Zhuo Chen*. Development of Degraders of Cyclin-Dependent Kinases 4 and 6 Based on Rational Drug Design.J. Med. Chem. 2024, 67, 11354−11364.
2.Huan He#, Mengting Xie#, Mengting Zhang#, Haiqin Zhang, Huan Zhu, Yuxian Fang, Zihao Shen, Rui Wang, Zhenjiang Zhao*, Lili Zhu*, Xuhong Qian*, Honglin Li*. Design, synthesis and biological evaluation of potent and selective S1PR1 agonists for the treatment of Ulcerative Colitis.Chin. J. Chem.2022, 40, 2625—2632（Cover paper）
3.Huan He#, Qi Liu#, Lu Chen#, Jie Wang#, Yuan Yuan, Xuhong Qian, Honglin Li, Zhuo Chen*, Zhenjiang Zhao*. Design, synthesis and biological evaluation of pteridine-7(8H)-one derivatives as potent and selective CDK4/6 inhibitors.Bioorg. Med. Chem. Lett. 76 (2022) 128991
4. Yu An#,Huan He#, Tingting Liu, Yong Zhang, Xiaoyun Lu, Qian Cai*. Diversified Synthesis of 2-(4-Oxo 1,2,3 triazolo 1,5-a quinoxalin-5(4H)-yl)acetamide Derivatives through Ugi-4-CR and Copper-Catalyzed Tandem Reactions.Synthesis. 2017, 49 (17), 3863-3873.
5.Qiang Ding,Huan He, Qian Cai*. Chiral Aryliodine-Catalyzed Asymmetric Oxidative C-N Bond Formation via Desymmetrization Strategy.Org. Lett. 2018, 20 (15), 4554-4557.
6.Yong Zhang,Huan He, Qiuyan Wang, Qian Cai*. Asymmetric synthesis of chiral P-stereogenic triaryl phosphine oxides via Pd-catalyzed kinetic arylation of diaryl phosphine oxides.Tetrahedron Lett.2016,57 (48), 5308-5311.
