高威

学习经历：

1996/09-2000/07      天津科技大学                学士/本科

2000/09-2003/07      南开大学                    硕士/研究生

2005/07-2010/11      香港大学                    博士/研究生

工作经历：

2011/08-2016/09  香港大学李嘉诚医学院             博士后

2016/10-2021/04  香港大学李嘉诚医学院             助理教授（研究）

2021/10-2022/09  香港中文大学科比尔卡创新药物开发研究院   研究员

2022/09-至今         华东师范大学药学院               副教授

荣誉及奖励：

上海市浦江计划人才

深圳市孔雀计划人才

社会任职：

Frontiers in Oncology杂志编委

研究方向：

结构药理学：依据结构的G蛋白偶联受体（GPCR）药物研发

肿瘤药理学：靶向GPCR的抗肿瘤药物开发

发表论文：

1. Pan X, Ye F, Ning P, Zhang Z, Li X, Zhang B, Wang Q, Chen G, Gao W, Qiu C, Wu Z, Li J, Zhu L, Xia J, Gong K, Du Y. Structural insights into ligand recognition and selectivity of the human hydroxycarboxylic acid receptor HCAR2. Cell Discov. 2023 Nov 28;9(1):118.

2. Wong TS, Li G, Li S, Gao W, Chen G, Gan S, Zhang M, Li H, Wu S, Du Y. G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders. Signal Transduct Target Ther. 2023 May 3;8(1):177.

3. Wong TS*#, Gao W*#, Chen G, Qiu C, He G, Ye F, Wu Z, Zeng Z, Du Y#. Cryo-EM structure of orphan G protein-coupled receptor GPR21. MedComm (2020). 2023 Jan 25;4(1):e205. *Equal contributors;#Corresponding author

4. Ye F, Wong TS, Chen G, Zhang Z, Zhang B, Gan S, Gao W, Li J, Wu Z, Pan X, Du Y. Cryo-EM structure of G-protein-coupled receptor GPR17 in complex with inhibitory G protein. MedComm (2020). 2022 Sep 10;3(4):e159.

5. Gao W, Hu L, Zhang M, Liu S, Xu S, Chow VL, Chan JY, Wong TS. Mitochondrial DHODH regulates hypoxia-inducible factor 1 expression in OTSCC. Am J Cancer Res. 2022 Jan 15;12(1):48-67

6. Gao W, Xu S, Zhang M, Liu S, Siu SP, Peng H, Ng JC, Tsao GS, Chan AW, Chow VL, Chan JY, Wong TS. NADPH oxidase 5α promotes the formation of CD271 tumor-initiating cells in oral cancer. Am J Cancer Res. 2020 Jun 1;10(6):1710-1727.

7. Zhang M*, Gao W*, Liu S, Siu SP, Yin M, Ng JC, Chow VL, Chan JY, Wong TS. CD38 triggers inflammasome-mediated pyroptotic cell death in head and neck squamous cell carcinoma. Am J Cancer Res. 2020;10(9):2895-2908. *Equal contributors

8. Gao W, Li JZ, Chen SQ, Chan JY, Yin M, Zhang MJ, Wong TS. Epstein-Barr virus encoded microRNA BART7 regulates radiation sensitivity of nasopharyngeal carcinoma. Oncotarget. 2017;8(12):20297-20308.

9. Wong TS, Li JZ, Chen SQ, Chan JY, Gao W*. The Efficacy of Triamcinolone Acetonide in Keloid Treatment: A Systematic Review and Meta-analysis. Front Med (Lausanne). 2016;3:71.*Corresponding author

10. Gao W, Li JZ, Chen SQ, Chu CY, Chan JY, Wong TS. Decreased brain-expressed X-linked 4 (BEX4) expression promotes growth of oral squamous cell carcinoma. J Exp Clin Cancer Res. 2016;35(1):92.

11. Wei FQ, Sun W, Wong TS, Gao W, Wen YH, Wei JW, Wei Y, Wen WP. Eliciting cytotoxic T lymphocytes against human laryngeal cancer-derived antigens: evaluation of dendritic cells pulsed with a heat-treated tumor lysate and other antigen-loading strategies for dendritic-cell-based vaccination. J Exp Clin Cancer Res. 2016;35(1):18.

12. Gao W, Shi Y, Liu W, Lin WY, Wu JC, Chan JY, Wong TS. Diagnostic value of methylated human telomerase reverse transcriptase in human cancers: A meta-analysis. Front Oncol. 2015;5:296.

13. Gao W, Chan JY, Wong TS. Curcumin exerts inhibitory effects on undifferentiated nasopharyngeal carcinoma by inhibiting the expression of miR-125a-5p. Clin Sci (Lond). 2014;127(9):571-9.

主持科研项目：

1、上海市浦江人才计划D类

项目号：22PJD023

题目：开发GPR34拮抗剂用于癌症治疗

起始日期：2022-10-01至2024-9-30

经费：30万

2、国家自然科学基金委员会面上项目

项目号：81773136,

题目：二氢乳清酸脱氢酶通过上调乏氧诱导因子HIF-1表达促进口腔鳞癌转移的机制研究

起始日期：2018-01-01至2021-12-31,

经费：50万元

3、Health and Medical Research Fund - Full Grant (#06171936)

Project title: The role of GFPT2 in head and neck squamous cell carcinoma

Award: HK$1,426,240        

Funding period: 2019 – 2022

4、S.K. Yee Medical Foundation Grant (#2161219)

Project title: Determination of human papillomavirus status in head and neck cancer

Award: HK$542,000                                                             Funding period: 2017 – 2019

5、S.K. Yee Medical Foundation Grant (#2141221)

Project title: Radiochemotherapy sensitivity test on throat cancer

Award: HK$485,099                                                             Funding period: 2015 – 2017

著作：

1. Wong TS, Gao W, Luo J, Chan JY. The risk and prognostic factors associated with undifferentiated nasopharyngeal carcinoma. Horizons in Cancer Research. Volume 56, Hiroto S Watanabe (eds.), Nova Science Publishers, 2015.

2. Gao W, Wong TS, Luo J, Chan JY. The growing significance of human epidermal growth factor receptor 2 (HER2) as therapeutic treatment target in head and neck cancer. Head and Neck Cancer: Epidemiology, Management and Treatment Outcomes, Madison R Hall (eds.), Nova Science Publishers, 2015.

3. Wong TS, Gao W, Li ZH, Matrix metalloproteinase family as molecular biomarkers in oral squamous cell carcinoma. Biomarkers in Disease: Methods, Discoveries and Applications. Biomarkers in Cancer. ID: 10, Preedy VR and Patel VB (eds.), Springer, 2015.

4. Wong TS, Gao W, Chan JY. Biomarkers in nasopharyngeal carcinoma and ionizing radiation. Biomarkers in Disease: Methods, Discoveries and Applications. Biomarkers in Cancer. Article ID: 432877, Chapter ID: 39, Preedy VR and Patel VB (eds.), Springer, 2015.

5. Wong TS, Chan JY, Gao W. The role of Epstein-Barr virus in the management of undifferentiated nasopharyngeal carcinoma. Epstein-Barr Virus (EBV): Transmission, Diagnosis and Role in the Development of Cancers, Nova Science Publishers, 2014.

6. Wong TS, Gao W, Chan JY. Curcumin suppresses angiogenesis, invasion and metastasis through inhibiting matrix metalloproteinases in human cancers. Curcumin: Synthesis, Emerging Role in Pain Management and Health Implications, Nova Science Publishers, 2014.

7. Tsang RKY, Gao W, Wong TS. Surgical treatment of the squamous cell carcinoma of the tongue and the effect on speech and swallowing, Tongue: Anatomy, Kinematics and Diseases (Human Anatomy and Physiology), 1-16, Kato H and Shimizu T (eds.), Nova Science, 2012.

8. Wong TS, Gao W, Ho WK, Chan YW, Tsang RKY. MicroRNA dysregulation in squamous cell carcinoma of head and neck, Squamous Cell Carcinoma, 255-280, Li X (eds.), Intech, 2012.

9. Chye ML, Xiao S, Chen QF, Gao W. Potential in using Arabidopsis acyl-coenzyme-A-binding proteins in engineering stress-tolerant plants. Section I, 6, 83-97, Biocatalysis and Biomolecular Engineering, Hou CT and Shaw JF (eds.), Wiley, 2010.