胡乔宇

发布者：何靖宇发布时间：2024-03-06浏览次数：1139

胡乔宇副研究员

工作单位：华东师范大学药学院

职称、职务：副研究员

邮箱：qyuhu@hsc.ecnu.edu.cn









学习经历：

2007.09-2011.06中国石油大学（北京）学士 化学工程与工艺

2011.09-2014.06中国科学院大学（过程所）硕士 化学工艺

2014.08-2020.06迈阿密大学（美国）博士 计算化学


工作经历：

2020.10-2022.10上海科技大学 博后

2022.11-至今 华东师范大学 副研究员


荣誉及奖励：

2008.07国家奖学金,中华人民共和国教育部

2009.07中国海洋石油奖学金,中国石油大学（北京）

2014.06中国环境科学奖学金,中国科学院大学

2018.09 Sam&Clara暑期研究奖学金，美国迈阿密大学

2021.12上海市“超级博士后”激励计划，上海市人力资源和社会保障局


研究方向：

计算化学、计算生物学、人工智能药物设计


发表论文：

  1. Qiaoyu Hu, Hari Paudyal, Junmei Zhao, Fang Huo, Katsutoshi Inoue, Huizhou Liu. Adsorptive recovery of vanadium(V) from chromium(VI) - containing effluent by Zr(IV)-loaded orange juice residue,Chemical Engineering Journal, 2014, 248, 79-88.

  2. Qiaoyu Hu, Junmei Zhao, Fuchun Wang, Na Sui, Xiaoqin Wang, Fang Huo, Huizhou Liu. Selective extraction of vanadium from chromium by pure [C8mim][PF6]: an anion exchange process,Separation and Purification Technology, 2014, 131, 94-101.

  3. Junmei Zhao,Qiaoyu Hu, Yingbo Li, Huizhou Liu. Efficient separation of vanadium and chromium by a novel ionic liquid-based synergistic extraction strategy,Chemical Engineering Journal, 2015, 264, 487-496.

  4. Fuchun Wang, Junmei Zhao, Xuetuan Wei, Fang Huo, Wensong Li,Qiaoyu Hu, Huizhou Liu. Adsorption of rare earths (III) by calcium alginate - poly glumatic acid hybrid gels,Journal of Chemical Technology and Biotechnology,2014, 89, 969-977.

  5. Qiaoyu Hu, Vindi M. Jayasinghe-Arachchige, Joshua Zuchniarz, Rajeev Prabhakar. Effects of the Metal Ion on the Mechanism of Phosphodiester Hydrolysis Catalyzed by Metal-Cyclen Complexes.Frontiers in Chemistry, 2019, 7, 195.

  6. Qiaoyu Hu, Vindi M. Jayasinghe-Arachchige, Gaurav Sharma, Leonardo F. Serafim, Thomas J. Paul and Rajeev Prabhakar. Mechanisms of Peptide and Phosphoester Hydrolysis Catalyzed by Two Promiscuous Metalloenzymes (Insulin Degrading Enzyme and Glycerophosphodiesterase) and Their Synthetic Analogues. WIREs Computational Molecular Science, 2020, 10, e1466.

  7. Qiaoyu Hu, Vindi M. Jayasinghe-Arachchige, Rajeev Prabhakar.Degradation of a Main Plastic Pollutant Polyethylene Terephthalate by Two Distinct Proteases (Neprilysin and Cutinase-like Enzyme).Journal of Chemical Information and Modeling, 2021, 61, 764-776.

  8. Qiaoyu Hu, Kevin Padron, Daiki Hara, Junwei Shi, Alan Pollack, Rajeev Prabhakar, Wensi Tao. Interactions of Urea-Based Inhibitors with Prostate-Specific Membrane Antigen for Boron Neutron Capture Therapy.ACS Omega, 2021, 6, 33354-33369.

  9. Vindi M. Jayasinghe-Arachchige,Qiaoyu Hu, Gaurav Sharma, Thomas J. Paul, Marcus Lundberg, David Quiñonero, Tatjana N. Parac-Vogt and Rajeev Prabhakar. Hydrolysis of Chemically Distinct Sites of Human Serum Albumin (HSA) by Polyoxometalate (POM): A Hybrid QM/MM (ONIOM) Study. Journal of Computational Chemistry, 2019, 40, 51-61.

  10. Gaurav Sharma,Qiaoyu Hu, Vindi M. Jayasinghe-Arachchige, Thomas Paul, Gerhard Schenk and Rajeev Prabhakar. Investigating Coordination Flexibility of Glycerophosphodiesterase (GpdQ) Through Interactions with Mono-, Di-, and Triphosphoester (NPP, BNPP, GPE, and Paraoxon) Substrates.Physical Chemistry Chemical Physics, 2019, 21, 5499-5509.

  11. Thomas M. Carlino,Qiaoyu Hu, Amy M. Scott. Aggregate Induced Self-Assembly and Ultrafast Dynamics of Light-Harvesting D-A-A Polymorphs.Macromolecular Rapid Communications, 2018, 39, 1800391.

  12. Gaurav Sharma, Vindi M. Jayasinghe-Arachchige, Qiaoyu Hu, Gerhard Schenk and Rajeev Prabhakar. The Effect of Chemically Distinct Substrates on the Mechanism and Reactivity of a Highly Promiscuous Metallohydrolase. ACS Catalysis, 2020, 10, 3684-3696.

  13. Mercedes M. A. Mazza, Shiori Yamazaki, Dieu X. Mai,  Suyog Padgaonkar, Samuel Peurifoy, Ariane Goncalves, Yi-Lin Wu, Qiaoyu Hu, Amy M. Scott. Photoinduced charge recombination in dipolar D-A-A photonic liquid crystal polymorphs.Physical Chemistry Chemical Physics, 2017, 19, 4588-4596.

  14. Fenglei Li,Qiaoyu Hu, Ruofan Xiong, and Fang Bai. Computational drug design methods by deep learning algorithms.Chinese Journal of Nature, 2021, 43(5): 383-390.

  15. Fenglei Li1,Qiaoyu Hu1, Xianglei Zhang1, Renhong Sun1, Zhuanghua Liu1, Sanan Wu, Siyuan Tian, Xinyue Ma, Zhizhuo Dai, Xiaobao Yang, Shenghua Gao, and Fang Bai. DeepPROTACs is a deep learning-based targeted degradation predictor for PROTACs.Nature Communications, 2022, 13, 7133.

  16. Zhongneng Zhou, Zijing Chen, Xiu-Wen Kang, Yalin Zhou, Bingyao Wang, Siwei Tang, Shuhua Zou, Yifei Zhang,Qiaoyu Hu, Fang Bai, Bei Ding, and Dongping Zhong. The nature of proton-coupled electron transfer in a blue light using flavin domain. Proceedings of the National Academy of Sciences of the United States of America, 2022, 119(26), e2203996119.

  17. Pengxuan Ren1, Changyue Yu1, Ruxue Zhang1, Tianqing Nie1,Qiaoyu Hu1, Hui Li, Xianglei Zhang, Xueyuan Zhang, Shiwei Li, Lu Liu, Wenhao Dai, Jian Li, Yechun Xu, Haixia Su, Leike Zhang, Hong Liu, Fang Bai. Discovery, synthesis and mechanism study of 2, 3, 5-substituted [1, 2, 4]-thiadiazoles as covalent inhibitors targeting 3C-Like protease of SARS-CoV-2. European Journal of Medicinal Chemistry, 2023, 249, 115129.

  18. Vindi M. Jayasinghe-Arachchige, Leonardo F. Serafim,Qiaoyu Hu, Cihan Ozen, Sreerag N. Moorkkannur, Gerhard Schenk, Rajeev Prabhakar. Elucidating the Roles of Distinct Chemical Factors in the Hydrolytic Activities of Hetero- and Homonuclear Synthetic Analogues of Binuclear Metalloenzymes.ACS Catalysis, 2023, 13, 3131-3147.

  19. Yanyan Diao, Dandan Liu, Huan Ge, Rongrong Zhang, Kexin Jiang, Kai Zhang, Rui Wang, Lili Zhu, Zhenjiang Zhao,Qiaoyu Hu, and Hongling Li. Macrocyclization of linear molecules by deep learning to facilitate macrocyclic drug candidates discovery.Nature Communications, 2023, 14, 4552.


科研成果：

专利：白芳，高盛华，蒋华良，李风雷，胡乔宇，刘壮华；基于神经网络的PROTAC分子降解率的预测系统及其构建方法，2021-9-07，中国，202111043888.3。

著作：《人工智能与药物设计》第九章